تفاصيل الوثيقة

نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
IL-33 attenuates EAE by suppressing IL-17 and IFN-γ production and inducing alternatively activated macrophages
IL-33 attenuates EAE by suppressing IL-17 and IFN-γ production and inducing alternatively activated macrophages
 
لغة الوثيقة : الانجليزية 
المستخلص : Interleukin (IL)-33, a member of the IL-1 cytokine family, is an important modulator of the immune system associated with several immune-mediated disorders. High levels of IL-33 are expressed by the central nervous system (CNS) suggesting a potential role of IL-33 in autoimmune CNS diseases. We have investigated the expression and function of IL-33 in the development of experimental autoimmune encephalomyelitis (EAE) in mice. We report here that IL-33 and its receptor ST2 (IL-33Rα) are highly expressed in spinal cord tissue, and ST2 expression is markedly increased in the spinal cords of mice with EAE. Furthermore, ST2-deficient (ST2(-/-) ) mice developed exacerbated EAE compared with wild-type (WT) mice while WT, but not ST2(-/-) EAE mice treated with IL-33 developed significantly attenuated disease. IL-33-treated mice had reduced levels of IL-17 and IFN-γ but produced increased amounts of IL-5 and IL-13. Lymph node and splenic macrophages of IL-33-treated mice showed polarization toward an alternatively activated macrophage (M2) phenotype with significantly increased frequency of MR(+) PD-L2(+) cells. Importantly, adoptive transfer of these IL-33-treated macrophages attenuated EAE development. Our data therefore demonstrate that IL-33 plays a therapeutic role in autoimmune CNS disease by switching a predominantly pathogenic Th17/Th1 response to Th2 activity, and by polarization of anti-inflammatory M2 macrophages. 
ردمد : 1521-4141 
اسم الدورية : European journal of immunology 
المجلد : 42 
العدد : 7 
سنة النشر : 1433 هـ
2012 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Thursday, March 10, 2016 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
Hui‐Rong JiangJiang, Hui‐Rong باحث رئيسي huirong.jiang@strath.ac.uk
Marija MilovanovićMilovanović, Marija باحث مشارك  
Debbie AllanAllan, Debbie باحث مشارك  
Wanda NiedbalaNiedbala, Wanda باحث مشارك  
Anne‐Galle BesnardBesnard, Anne‐Galle باحث مشارك  
Sandra Y FukadaFukada, Sandra Y باحث مشارك  
Jose C Alves‐FilhoAlves‐Filho, Jose C باحث مشارك  
Dieudonnée TogbeTogbe, Dieudonnée باحث مشارك  
Carl S GoodyearGoodyear, Carl S باحث مشارك  
Christopher LiningtonLinington, Christopher باحث مشارك  

الملفات

اسم الملفالنوعالوصف
 38520.pdf pdf 

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