Princess Al-Jawhara Center of Excellence in Research of Hereditary Disorders | Researches | Recommendations for Genetic Variation Data Capture in Developing Countries to Ensure a ComprehensiveWorldwide Data Collection

Princess Al-Jawhara Center of Excellence in Research of Hereditary Disorders

Document Details

Document Type	:	Article In Journal
Document Title	:	Recommendations for Genetic Variation Data Capture in Developing Countries to Ensure a ComprehensiveWorldwide Data Collection توصيات لجمع بيانات الاختلاف الجيني في الدول النامية لضمان وجود بيانات شاملة من مختلف دول العالم
Subject	:	HVP
Document Language	:	English
Abstract	:	Developing countries have significantly contributed to the elucidation of the genetic basis of both common and rare disorders, providing an invaluable resource of cases due to large family sizes, consanguinity, and potential founder effects. Moreover, the recognized depth of genomic variation in indigenous African populations, reflecting the ancient origins of humanity on the African continent, and the effect of selection pressures on the genome, will be valuable in understanding the range of both pathological and nonpathological variations. The involvement of these populations in accurately documenting the extant genetic heterogeneity is more than essential. Developing nations are regarded as key contributors to the Human Variome Project (HVP; http://www.humanvariomeproject.org), a major effort to systematically collect mutations that contribute to or cause human disease and create a cyber infrastructure to tie databases together. However, biomedical research has not been the primary focus in these countries even though such activities are likely to produce economic and health benefits for all. Here, we propose several recommendations and guidelines to facilitate participation of developing countries in genetic variation data documentation, ensuring an accurate and comprehensive worldwide data collection. We also summarize a few well-coordinated genetic data collection initiatives that would serve as paradigms for similar projects.
ISSN	:	21397
Journal Name	:	Human Mutation
Volume	:	31
Issue Number	:	0
Publishing Year	:	1431 AH 2010 AD
Article Type	:	Article
Added Date	:	Saturday, December 18, 2010

Researchers

Researcher Name (Arabic)	Researcher Name (English)	Researcher Type	Dr Grade	Email
جيورج ب باترينوس	Patrinos, George P	Investigator	Doctorate	gpatrinos@upatras.gr
جمانة يوسف الأعمى	Al Aama, Jumana Yousuf	Researcher	Doctorate	jalama@kau.edu.sa

Files

File Name	Type	Description
28180.pdf	pdf

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